Table 4.

Adjusted LV mass index (g/m² body surface area) by categories of cystatin C-based estimated glomerular filtration rate (eGFR_cysC) in 4,536 MESA participants with a creatinine-based eGFR > 60 ml/min/1.73 m²

		Demographic Adjusted*		Adjusted for demographic variables, smoking, and diabetes†		Adjusted for demographic variables, smoking, diabetes, and hypertension‡
	Number	Mean LV mass index (g/m2) (95% CI)	P value	Mean LV mass index (g/m2) (95% CI)	P value	Mean LV mass index (g/m2) (95% CI)	P value
Cystatin C eGFR∥
> 75	3874	77.6 (77.2, 78.1)	Ref	77.6 (77.2, 78.1)	Ref	77.7 (77.3, 78.1)	Ref
60-75	587	80.1 (78.9, 81.3)	<0.001	80.0 (78.8, 81.1)	0.001	79.6 (78.4, 80.7)	0.009
<60	75	78.8 (75.6, 82.0)	0.8	78.5 (75.2, 81.7)	0.9	77.8 (74.7, 80.9)	0.9
Cystatin C eGFR
> 75	3874	77.6 (77.2, 78.1)	Ref	77.6 (77.2, 78.1)	Ref	77.7 (77.3, 78.1)	Ref
<=75	662	79.9 (78.8, 81.1)	<0.001	79.8 (78.7, 80.9)	<0.001	79.4 (78.3, 80.5)	0.005

^*adjusted for age, sex, race/ethnicity, and MESA site

^†diabetes defined as fasting serum glucose ≥ 126 mg/dL (7 mmol/l) or taking insulin or oral diabetes medications

^‡hypertension defined as systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg, or taking antihypertensive medications

^§pairwise comparisons using the highest eGFR category as the reference group (i.e. highest with middle, highest with lowest). Sidak test used.

^∥eGFR = glomerular filtration rate estimated using cystatin C(26)