Figure 8. The Δpdr1::pdr1DBD-cyc8 insertion construct enhances the sensitivity of yeast to a wide range of anti-cancer drugs.

Logarithmically growing cells were spotted onto plates following 24 hr drug treatment in liquid. An assortment of small molecules/drugs as described in the text was assessed. All drugs were tested at 250μM, except dactinomycin (2μM). Five positive compounds are illustrated. Other positive compounds are not shown, and a list of test compounds is available on request.