Table 3.

Areas of Blood Flow Increases (↑) and Decreases (↓) During Exposure to Traumatic Scripts Relative to Neutral Scripts

		Healthy Controls			MVC Subjects
		Talairach Coordinates	Z-score	k	Talairach Coordinates	Z-score	k^*
Trauma Script vs. Personalized Neutral script
	Right amygdala (↓)^†				26, −3, −17	3.75	69
	Left amygdala/perirhinal cortex^a (↓)^††				−28, 1, −27	4.37	33
Trauma script vs. Standardized Neutral Script
	Left mPFC (↑) (BA 32/10) ^†	−22, 42, 16	3.96	45
	Left mPFC (↑) (BA 10) ^†				−12, 46, −7	4.66	124
	Right insula (↑)^†				40, 17, −9	3.87	149
	Left hippocampus (↓)^†				−28, −11, −16	4.03	101

Correction for multiple comparisons within regions was performed by Familywise Error adjustment and small volume correction.

MVC = motor vehicle collision group

k = cluster size and is reported for the SVC analysis thresholded at 0.005.

In the whole brain analysis performed post hoc the peak voxel T-value within this cluster of similarly valenced T-values localized these coordinates to the perirhinal cortex ventral to the amygdala.

^†

Post hoc analysis using a random effects model (p < .05 uncorrected) directly comparing MVC and HC groups revealed a significantly greater change in rCBF in the reported group in the direction indicated by the arrow at the voxels identified.

^††

Post hoc analysis using a random effects model (p < .05 uncorrected) directly comparing MVC and HC groups revealed a trend for greater deactivation at this location in the MVC group.