Table 5.

Significant Positive (+) and Negative (−) Correlations Between rCBF and Amygdala Seed Regions During Trauma vs. Personalized Neutral Script Listening in MVC subjects (no region was identified where rCBF correlated significantly with amygdala flow in the healthy controls)

		MVC Subjects
Seed Region	Brain Region (Brodmann Area)	Talairach Coordinates	Z-score	k^*
Left Amygdala
	Right hippocampus^a (+)^†	34, −13, −21	3.73	109
	Right hippocampus (+)^†	42, −18, −11	3.98	109
	Right ACC (BA 24/32) (+)^†	12, 36, 11	3.92	46
	Right anterior insula^b(+)^†	38, 11, −14	4.04	30
	Left anterior insula (+)	−32, 18, 7	3.76	50
Right Amygdala
	Left hippocampus (+)^†	−34, −16, −14	3.60	35

Correction for multiple comparisons within regions was by Familywise Error adjustment and small volume correction.

MVC = motor vehicle collision group. ACC = anterior cingulate cortex; mPFC = medial prefrontal cortex.

k = cluster size and is reported for the SVC analysis thresholded at 0.005.

This peak was first identified as right amygdala upon SVC analysis, but post hoc analysis revealed the whole brain peak to lie in the right hippocampus at the coordinates described.

These coordinates localize to cortex along the Sylvian fissure at the junction of the insula and the temporal cortices.

^†

Post hoc analysis using a random effects model (p < .05 uncorrected) directly comparing MVC and HC groups revealed a significantly greater correlation between rCBF in the seed region and in the reported voxels in the MVC group relative to the HC group.