Table 1.

Spike train variability and burst structure for transgenic and knock-in mouse models of HD and corresponding WT littermates

	WT			R6/2 or KI
	Median	Range	25th to 75th percentile	Median	Range	25th to 75th percentile
Transgenic model (R6/2)
Variability
CV ISI	1.338*	1.005–9.583	1.198–1.579	1.258	0.929–3.688	1.147–1.417
Burst structure
Duration (s)	1.283†	0.191–14.07	0.759–2.288	1.006	0.166–34.90	0.062–2.128
Spikes/s	24.92†	2.579–160.3	14.71–43.39	31.85	1.473–114.8	16.90–49.64
Spikes/burst	15.67	5.00–60.38	12.56–20.81	16.27	6.00–87.40	13.00–21.38
ISI in a burst (s)	0.098†	0.012–0.996	0.049–0.137	0.068	0.012–0.927	0.036–0.126
Knock-in model (KI)
Variability
CV ISI	1.28	0.097–11.83	1.158–1.50	1.316	1.030–3.289	1.201–1.583
Burst structure
Duration (s)	0.832	0.067–187.4	0.548–1.566	0.787	0.156–54.68	0.488–1.148
Spikes/s	40.95	0.176–123.5	25.21–58.77	38.91	0.463–180.0	21.38–58.79
Spikes/burst	15.59	4.80–48.63	12.54–19.82	15.15	7.054–36.11	12.67–19.84
ISI in a burst (s)	0.057	0.014–5.680	0.039–0.096	0.053	0.008–3.212	0.034–0.102

*p < 0.01, significant difference between medians of R6/2 and WT.

^†p < 0.0001, significant differences between medians of WT mice from the transgenic and WT mice of the KI line.