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EC50 values for various PAQR ligands.
| log EC50 nM (EC50) | ||
|---|---|---|
| mPRγ | mPRα | |
| Progesterone | 0.04 ± 0.25 (1.1 nM) |
0.34 ± 0.08 (2.2 nM) |
| 17α-hydroxyprogesterone | 0.97 ± 0.63 (9.3 nM) |
1.01 ± 0.44 (10.2 nM) |
| RU-486 | 3.83 ± 0.23 (6.8 µM) |
4.04 ± 0.26 (11.0 µM) |
| Progesterone + 10 µM Testosterone |
1.03 ± 0.53 (10.7 nM) |
N.D. |
| Progesterone + 100 nM RU-486 |
1.19 ± 0.12 (15.5 nM) |
N.D. |
N.D. Not determined
