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. 2008 Aug 13;28(33):8354–8360. doi: 10.1523/JNEUROSCI.0616-08.2008

Figure 3.

Figure 3.

Reduced expression of Aβ-binding receptors in microglia from old transgenic PS1-APP mice. Expression of Aβ-binding receptors in CD11b+ cells was compared between transgenic PS1-APP mice and their age-matched WT littermates at 1.5, 3, 8, and 14 months of age. Data represent the average values obtained by QPCR on six sets of mice for 3 and 14 months of age and on five sets of mice at 1.5 and 8 months of age. *Values of p are shown only if differences are significant (<0.05). A, B, D, At 8 and 14 months of age, PS1-APP transgenic mice show significantly reduced expression of SRA (A), CD36 (B), and RAGE (D) compared with their WT littermates. C, There are no significant differences in expression of SRB1 observed between transgenic and WT mice at any age. E, There was negligible expression of MARCO. Error bars indicate SEM.