Skip to main content
. 2008 Aug 13;28(33):8354–8360. doi: 10.1523/JNEUROSCI.0616-08.2008

Figure 4.

Figure 4.

Decreased expression of Aβ-degrading enzymes in microglia from old transgenic PS1-APP mice. Expression of Aβ-degrading enzymes in CD11b+ cells from transgenic PS1-APP mice was compared with their age-matched wild-type littermates at 1.5, 3, 8, and 14 months of age. Data are expressed for transgenic mice as percentage expression of WT. *Values of p are only shown if differences are significant. A–C, Expression of insulysin (A), neprilysin (B), and MMP9 (C), enzymes thought to degrade Aβ, is comparable across WT and transgenic microglia from mice at 1.5 and 3 months of age. A, In 8-month-old PS1-APP transgenic mice, there is a statistically significant reduction only in insulysin RNA levels. However, by 14 months of age, the reduction in expression of all three enzymes is statistically significant (A–C). The horizontal lines across the graphs indicate 100% WT levels. Error bars indicate SEM.