Figure 5.

Increased expression of IL-1β and TNFα in microglia from old transgenic PS1-APP mice. A, B, Expression of IL-1β (A) and TNFα (B) was measured by QPCR in CD11b⁺ cells from transgenic PS1-APP mice and their age-matched, nontransgenic littermates at 1.5, 3, 8, and 14 months of age. Data are displayed for transgenic mice as percentage expression of their WT littermates at the same ages. In young mice (1.5 and 3 months of age), expression of IL-1β (A) and TNFα (B) is comparable across all groups, but at 8 and 14 months of age there are significant increases (p < 0.05) in RNA expression of both IL-1β and TNFα in transgenic compared with WT mice. Error bars indicate SEM.