Figure 1.
800 MHz 1H-15N shift correlation of tRNAVal. (A) Part of the imino region of the superimposed 2D 15N-1H TROSY-HSQC (blue) and regular HSQC (red) correlation spectra of tRNAVal recorded at 800 MHz, 28 °C, showing correlations for the imino groups of G nucleotides. (B) Expanded cross peak for the TROSY imino correlation of U64, which forms a wobble base pair with G50 and experiences extensive homonuclear 1H-1H RDC with adjacent protons. 15N-1H/1H-1H dipolar cross correlated relaxation results in asymmetry of the unresolved 1H-1H multiplet.