Skip to main content
. Author manuscript; available in PMC: 2008 Dec 8.
Published in final edited form as: Nat Rev Microbiol. 2008 Mar 3;6(4):266–275. doi: 10.1038/nrmicro1855

Figure 4. Summary of the effects of mammalian DNA viruses on the components of the PI3K–Akt–mTOR pathway, the substrates of mTORC1 and the eIF4F complex.

Figure 4

The many activating and inhibitory mechanisms that are used by DNA viruses to maintain mTOR complex 1 (mTORC1) activity and cap-dependent translation are summarized. However, it should be noted that these effects might also provide many other physiological changes in the cell that can benefit a productive viral infection and contribute to viral pathogenesis. 4E-BP, eIF4E binding protein; AD, adenovirus; eIF, eukaryotic elongation factor; HCMV, human cytomegalovirus; HPV, human papillomavirus; HSV, herpes simplex virus; Mnk1, mitogen-activated protein kinase-interacting kinase 1; mTOR, mammalian target of rapamycin; MV, myxoma virus; PDK1, phosphoinositide-dependent protein kinase 1; PI3K, phosphatidylinositol 3′ kinase; PP2A, protein phosphatase 2A; S6, ribosomal protein S6; S6K, p70S6 kinase; ST, small tumour antigen; SV, simian virus 40; TSC, tuberous sclerosis complex; VV, vaccinia virus.