Table 4.

Multivariable modeling results for TNF

Multivariable Model of TNF†
Predictor		Estimate (95% CI)	P Value
Time (min)	0	Reference
	15	4.9  (3.2, 7.4)	< 0.0001‡
	30	4.6  (2.9, 7.3)	< 0.0001‡
	60	3.6  (2.2, 5.9)	< 0.0001‡
	90	3.1  (1.9, 5.1)	< 0.0001‡
	120	3.0  (1.8, 4.9)	< 0.0001‡
	180	2.5  (1.5, 4.1)	0.0018‡
Gender	Male	Reference
	Female	0.8  (0.6, 1.1)	0.21
VF Type	Electrical	Reference
	Ischemic	3.5  (2.6, 4.6)	< 0.0001

^†Estimates are multiplicative factors, relative to a reference measurement of TNF in a male animal, undergoing electrical VF induction, at time zero. Estimates are based on models of log transformed values of TNF measurement plus one (see text for details).

^‡P Values corrected for multiple comparisons to baseline at time zero, using the Dunnett-Hsu correction.