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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Exp Neurol. 2008 May 29;213(1):114–121. doi: 10.1016/j.expneurol.2008.05.014

Figure 1.

Figure 1

Cultured cortical neuronal cells up-regulate expression of TLR4 when exposed to Aβ1-42. A. Levels of TLR 2, 3 and 4 mRNAs in neurons treated with Aβ (10 μM) for the indicated time periods. TLR4 mRNA levels increased in response to Aβ treatment, whereas TLR2 and TLR3 mRNA levels did not change. B. Immunoblot showing relative levels of TLR2 (95 KDa) and TLR4 (90 KDa) in lysates of cultured neurons that had been treated for 20 hours with vehicle (Control) or Aβ (1, 5 or 10 μM). Levels of TLR4, but not TLR2 or TLR3, were increased in response to Aβ treatment. Analyses were performed on pooled samples from 4-8 cultures.