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. Author manuscript; available in PMC: 2008 Dec 8.
Published in final edited form as: J Am Chem Soc. 2007 Feb 17;129(10):2808–2816. doi: 10.1021/ja0657556

Scheme 1.

Scheme 1

Cefotaxime hydrolysis catalyzed by (A) binuclear MβL CcrA from B.fragilis and (B) mononuclear BcII from B.cereus. The reactant state (R) corresponds to the ES complex, and the product state (P) corresponds to the EP complex.