Scheme 1.
Cefotaxime hydrolysis catalyzed by (A) binuclear MβL CcrA from B.fragilis and (B) mononuclear BcII from B.cereus. The reactant state (R) corresponds to the ES complex, and the product state (P) corresponds to the EP complex.
Cefotaxime hydrolysis catalyzed by (A) binuclear MβL CcrA from B.fragilis and (B) mononuclear BcII from B.cereus. The reactant state (R) corresponds to the ES complex, and the product state (P) corresponds to the EP complex.