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A: guanine quartet; B: antiparallel folding pattern for thrombin binding aptamer quadruplex determined by NMR 8; C: possible alternative antiparallel strand conformation; D: possible unimolecular parallel folding topology; E: possible bimolecular parallel folding topology. The 5′-end of the strand is indicated by the symbol ● while the 3′ end is indicated by ■; quartets are represented by dashed boxes
