Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neurobiol Aging. 2007 Jun 5;29(12):1783–1794. doi: 10.1016/j.neurobiolaging.2007.04.018

Figure 5. Nitrite production in peritoneal macrophages derived from ovariectomized APOE3 and APOE4 mice after replacement of endogenous estrogen.

Figure 5

Peritoneal macrophages from ovariectomized (OVX) mice and OVX mice treated with a slow release estrogen pellet (OVX + Est Pellet) were immune activated with LPS+IFNγ (A) or PIC+IFNγ (B). Average (±SEM) supernatant nitrite concentrations were determined and significant differences were calculated using 2-way ANOVA with the Bonferroni post-hoc test. A significant interaction was observed between APOE genotype and the treatment condition for both types of immune induction (p < 0.0001). # = p < 0.05 for APOE3 compared to APOE4; ## = p < 0.01 for APOE3 compared to APOE4; * = p < 0.05 for OVX + Est pellet compared to OVX alone; *** = p < 0.001 for OVX + Est pellet compared to OVX alone.