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Summary of new BCL2 inhibitors
| Agent | Phase | Disease |
|---|---|---|
| Oblimersen sodium | 2 | FL, DLBCL, WM, MM, NHL |
| 3 | MM | |
| Obatoclax mesylate | 1 | MCL |
| 2 | MDS, FL, HL | |
| ABT-263 | 2 | CLL, FL (combined with rituximab) |
CLL, chronic lymphocytic leukemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; HL, Hodgkin’s lymphoma; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MM, multiple myeloma; NHL, non-Hodgkin’s lymphoma; WM, Waldenstrom’s macroglobulinemia
