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Nifuroxazide inhibits STAT3-dependent gene expression. (A) Chemical structure of nifuroxazide. (B) STAT3 and NF-κB reporter cells were pretreated with nifuroxazide at the indicated concentrations for 1 hour, after which cells were stimulated with IL-6 or TNF-α, respectively, for 6 hours. Luciferase activity was quantitated by luminometry.
