Table 1.
Effect of FoxM1 knockdown on glioma growth in the brain of nude mice a
Cell Line | Incidence of tumor formation b | Survival Median Days c (range) |
---|---|---|
HFU-251MG | 5/5 | 37 (34 – 53) |
HFU-251MG-Control-shRNA | 5/5 | 34 (All 34) |
HFU-251MG-FoxM1-shRNA-a | 0/5 | 90 (All >90) * |
HFU-251MG-FoxM1-shRNA-b | 0/5 | 90 (All >90) * |
| ||
U-87MG | 5/5 | 31 (25–36) |
U-87MG-Control-shRNA | 5/5 | 29 (23–34) |
U-87MG-FoxM1-shRNA-a | 0/5 | 90 (All >90)* |
U-87MG-FoxM1-shRNA-b | 1/5 | 84 (61 – >90)* |
Glioma cells (1 × 106 cells) were implanted intracranially into nude mice. Mice were killed when they were moribund or on day 90. Brains were harvested, and tumor formation was determined by histology.
Incidence: number of mice with tumor/number of mice injected.
The survival time for brain tumor-free animal was recorded as 90 days.
p < 0.001.
Results were shown for one representative experiment of two with similar findings.