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Figure 2. Plots of the fraction of DNA (CII5T) bound vs the concentration of enzyme. WT (●), I260Q (○).
The Kaleidagraph graphics program was used to plot the data, and the data were fit as described in Experimental Procedures to obtain the KD. KD for WT is 9.3 ±1.5 nM and for I260Q=1.8±0.2nM.