Figure 2. Small intestinal permeability is reduced with a zonulin antagonist AT-1001. (A) Small intestinal permeability was measured in IL10−/− mice treated with high dose AT-1001 (open squares), low dose (open circles) or placebo (closed circles) from 4 to 17 weeks of age. The shaded area represents the mean (3 SD) of the lactulose/mannitol ratios observed in wild-type mice. Mice treated with the high dose of AT-1001 eventually reached the wild-type range. (B) Statistical analysis of the areas under the curve of small intestinal permeabilities for each group. The permeabilities of the groups treated with AT-1001 differed significantly from the placebo group; p<0.05 (low dose), p<0.01 (high dose), n = 10–13.
