Figure 6. Colonic secretion of interferon γ (IFNγ), tumour necrosis factor α (TNFα) and myeloperoxidase (MPO) content at 17 weeks. (A and B) The interleukin 10 gene-deficient (IL10−/−) mice had a significant increase in colonic secretion of these cytokines (p<0.05). This increase was prevented by treatment with the zonulin peptide inhibitor AT-1001 (n = 4–6). (C) The IL10−/− mice and the mice treated with the low dose had a significant increase in MPO content (p<0.05). High-dose treatment of AT-1001 prevented this increase (n = 4–6).
