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. Author manuscript; available in PMC: 2009 Aug 7.
Published in final edited form as: Regul Pept. 2008 Mar 25;149(1-3):15–25. doi: 10.1016/j.regpep.2007.08.024

Fig. 3. Simplified schematic diagram showing the neural systems responsible for satiation and meal size control.

Fig. 3

Hypothetical neuron in the nucleus tractus solitarius (NTS) receives information from gastrointestinal mechano- and chemo-sensors through vagal afferents and projects back to the gut via vago-vagal reflexes through the dorsal motor nucleus (DMV). Other outputs (heavy lines) of certain NTS neurons are directed towards the medullary reticular formation (Med. Ret. Form.) and eventually to brainstem motor nuclei responsible for oromotor control necessary to start and stop eating, as well as to forebrain areas, responsible for sustained satiety. Descending modulatory projections from hypothalamic areas are also shown (heavy dotted lines).