Table 1.
Population characteristics by IL6 –174 G/C genotype
| Characteristic | GG | GC | CC | |
|---|---|---|---|---|
| Total number – No. (%) | 1390 (36) | 1830 (48) | 629 (16) | |
| Age (yrs) | 72 ± 7 | 72 ± 7 | 73 ± 7 | |
| Male sex (%) | 42 | 43 | 41 | |
| BMI (kg/m2) | 27 ± 4 | 27 ± 9 | 27 ± 4 | |
| Systolic blood pressure (mm Hg) | 143 ± 21 | 143 ± 22 | 144 ± 21 | |
| Diastolic blood pressure (mm Hg) | 75 ± 11 | 75 ± 11 | 75 ± 11 | |
| MAP (mm Hg) | 106 ± 13 | 107 ± 13 | 107 ± 13 | |
| Total cholesterol (mmol/l) | 5.8 ± 1.0 | 5.8 ± 1.0 | 5.8 ± 0.9 | |
| HDL-cholesterol (mmol/l) | 1.4 ± 0.4 | 1.4 ± 0.4 | 1.4 ± 0.4 | |
| Smoking (%) | Current | 28 | 32 | 30 |
| Former | 39 | 37 | 38 | |
| Never | 33 | 31 | 32 | |
| Diabetes (%) | 8 | 9 | 10 | |
| IMT (mm) | 0.77 ± 0.14 | 0.78 ± 0.12 | 0.78 ± 0.14 | |
| Aortic calcifications (%)a | 22 | 23 | 20 | |
| PWV (m/s) | 13.4 ± 2.9 | 13.5 ± 3.1 | 13.8 ± 3.2 | |
| DC (1/MPa) | 10.4 ± 4.2 | 10.6 ± 4.4 | 10.1 ± 4.3 | |
| PP (mm Hg) | 68 ± 17 | 68 ± 18 | 69 ± 17 | |
| C-reactive protein (mg/L)b,d | 2.2 ± 2.3 | 2.6 ± 2.8 | 2.5 ± 2.7 | |
| Interleukin-6 (pg/mL)c,d | 2.1 ± 1.5 | 2.3 ± 1.7 | 2.2 ± 1.8 | |
Notes: Continuous values are depicted as mean ± SD; Number based on genotyped subjects with data on either PWV and/or DC and/or PP;aPercentage of subjects with aortic calcification over a length of ≥2.5 cm; bData available for 3556 subjects (n = 1285 [GG], n = 1694 [GC], n = 577 [CC]); cBased on random subgroup (n = 158 [GG], n = 212 [GC], n = 63 [CC]); dMeasured in samples obtained during first phase of Rotterdam Study.
Abbreviations: BMI, body mass index; DC, distensibility coefficient; IMT, intima media thickness; MAP, mean arterial pressure; PP, pulse pressure; PWV, pulse wave velocity; SD, standard deviation.