Table 7. Telemetry measurements in conscious α-MHC-LacZ-(CTG)400 mice.
LacZ (N = 5) | TGhigh (N = 14) | TGlow (N = 9) | One-way ANOVA | |
SCL (ms) | 99±5 | 88±9 | 88±8 | ns (0.06) |
HR (bpm) | 609±31 | 685±71 | 686±59 | ns (0.06) |
PR (ms) | 35.4±1.8* | 31.9±2.1* | 33.4±2.3 | p = 0.011 |
QRS (ms) | 14.6±0.7 | 14.0±1.5 | 14.8±1.0 | ns |
QT (ms) | 24.8±1.5 | 23.4±2.3 | 25.2±2.9 | ns |
QTc (ms) | 25.0±1.2 | 25.0±2.7 | 26.8±2.7 | ns |
Parameter values represent mean±standard deviation. Matching symbols (*) denote significant differences between groups in post hoc testing for that parameter; LacZ, α-MHC-LacZ-(CTG)0; TGhigh, α-MHC-LacZ-(CTG)400TGhigh; TGlow, α-MHC-LacZ-(CTG)400TGlow; SCL, sinus-cycle length; HR, heart rate; PR, atrial and A–V nodal conduction time; QRS, ventricular depolarization time; QT, surrogate of action potential duration; QTc, corrected surrogate of action potential duration; ms, milliseconds, bpm, beats per minute.