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. 2008 Dec 15;3(12):e3940. doi: 10.1371/journal.pone.0003940

Figure 6. There is increased cell death in the luminal epithelia of ARR2PBCreER(T2)×Ptenfl/fl mice exposed to OHT.

Figure 6

There were increased numbers of apoptotic cells within the luminal epithelium of ARR2PBCreER(T2)×Ptenfl/fl mice treated with OHT at 2 wks of age and aged for 6 wks (B) and also in ARR2PBCreER(T2)×Ptenfl/fl mice treated with OHT and aged for 4–10 wks (D). (E) Quantification of the percentage of apoptotic cells in control and ARR2PBCreER(T2)×Ptenfl/fl mice. There was a significant increase in the percentage of apoptotic cells over controls in ARR2PBCreER(T2)×Ptenfl/fl injected with OHT either at 2 wks and 6 wks of age (p-value<0.001). Scale bar: 50 µm.