. 2008 Dec 15;3(12):e3940. doi: 10.1371/journal.pone.0003940

Table 2. Morphologic alterations in the prostates of ARR2PBCreER(T2)×Pten^fl/fl mice injected at 2 wks of age, and subjected to histopathological analysis 10–12 wks post-OHT exposure.

Mouse Genotype	Abnormal cellular morphology¹	Atypical nuclear morphology² and increased number of nucleoli	Focal Hyperplasia	PIN lesions	Microinvasive carcinoma
Control Pten^fl/fl	0/4	0/4	0/4	0/4	0/4
Experimental ARR2PBCreER(T2)×Pten^fl/fl	6/6	6/6	6/6	6/6	2/6

Abnormal cellular morphology refers to nuclear enlargement, prominent nucleoli, hyperchromasia, and deviations in cell size and appearance.

Atypical nuclear morphology refers to nuclei displaying nuclear and nucleolar enlargement and increased number of nucleoli.

Table 2. Morphologic alterations in the prostates of ARR2PBCreER(T2)×Ptenfl/fl mice injected at 2 wks of age, and subjected to histopathological analysis 10–12 wks post-OHT exposure.