Fig. 1.

Example slices showing the enhancement of lesion tissue over time. The upper left image shows a typical field-of-view as it is used for simultaneous imaging of both breasts. The position of a region-of-interest (ROI) in the right breast is depicted by a white box. The white circle indicates the position of the lesion, which segmentation is presented in white. The remaining images show a magnified view of the ROI in the precontrast (upper right), first postcontrast (lower left) and fifth postcontrast (lower right) image. The lesion exposes a heterogeneous enhancement pattern: the intensity of the tissue in the lesion center continuously increases over time, whereas tissue at the lesion border reaches its peak intensity in the early postcontrast image and exposes lower intensity values in the late postcontrast image. These subtle differences in the temporal characteristics of the tissue are difficult to recognize in the original images but nevertheless important for the differential diagnosis of tumors.