Skip to main content
. Author manuscript; available in PMC: 2008 Dec 9.
Published in final edited form as: Drug Discov Today Dis Mech. 2007;4(4):223–230. doi: 10.1016/j.ddmec.2008.02.010

Figure 1.

Figure 1

Schematic representation of the three signaling pathways of apoptosis: The death receptor pathway through ligation of TNFR or Fas (extrinsic signaling), the mitochondrial pathway through Bcl-2 family members (intrinsic signaling), and the ER stress pathway. The two-pathway model of Fas/FasL signaling (Type I and Type II) is also illustrated. Bcl- 2 (B-cell CLL/lymphoma 2), Mcl-1 (myeloid cell leukemia sequence 1), A1 (B-cell leukemia/lymphoma 2 related protein A1), Bad (Bcl-2/Bcl-XL-associated death promotor), Bax (Bcl-2-associated X protein), Bim (Bcl-2 interacting mediator of cell death), Bid (BH3 interacting domain death agonist), ΔΨm (mitochondrial membrane potential); Apaf-1 (apoptosis-activating factor-1), FADD (Fas-associated death domain), TRADD (TNFR1-associated death domain), TRAF (TNFR associated factor), IAP (inhibitor of apoptosis proteins), FLIP (FADD-like interleukin-1-converting enzyme (FLICE)-inhibitory protein), ICAD, CAD ((inhibitor of) caspase-activated DNase)