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. Author manuscript; available in PMC: 2008 Dec 9.
Published in final edited form as: Drug Discov Today Dis Mech. 2007;4(4):223–230. doi: 10.1016/j.ddmec.2008.02.010

Figure 2.

Figure 2

A summary of the general changes in the levels of apoptosis (Ao) and/or activation induced cell death (AICD) reported both in experimental sepsis (filled arrows) in mice and septic-critically ill patients, as well as the mediators reported to affect the onset and frequency of Ao in various immune as well as non-immune cell types. Bcl-2 (B-cell CLL/lymphoma 2), NO (Nitric oxide), C5a (activated complement factor a), GALT (Gut associated lymphoid tissue), FasL (Fas-Ligand), TNF (Tumor necrosis factor), IL (Interleukin), Mcl-1 (myeloid cell leukemia sequence 1), A1 (B-cell leukemia/lymphoma 2 related protein A1), TUNEL (Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling)