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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 21;876(1):69–75. doi: 10.1016/j.jchromb.2008.10.022

Figure 3.

Figure 3

Examples of (a) frontal analysis results and (b) zonal elution competition studies for verapamil on an HSA column. The plot of 1/mL,app versus 1/[Verapamil] in (a) was prepared according to Eqns. (1) or (3) for S-verapamil, giving a best fit line of y = 0.47 (± 0.01) x + 0.023 (± 0.001) with a correlation coefficient of 0.999 (n = 5). The plot in (b) of 1/k versus [Verapamil] for injections of S-warfarin in the presence of racemic verapamil gave a best-fit line of y = 1.0 (± 0.1) × 10 4 x + 7.2 (± 0.1) × 10−3 with a correlation coefficient of 0.989 (n = 6). The numbers in parentheses and the error bars represent a range of ± 1 SD. All of these studies were conducted at 37°C in the presence of pH 7.4, 0.067 M phosphate buffer. Other experimental conditions are given in Section 2.3.