Table 3 Dominant‐negative activity of P53 mutations in the tumours.
| Tumour | Patient age (years) | Dukes stage | Recurrence* | P53 status | 309 | D‐neg activity† | AA change |
|---|---|---|---|---|---|---|---|
| 17 | 65 | B | NA | Mut | G | Negative | Arg282Trp |
| 113 | 73 | B | 1 | Mut | T | Negative | Arg282Trp |
| 130 | 75 | B | 0 | Mut | T | Negative | Arg231Stop |
| 142 | 91 | B | 0 | Mut | T | Negative | Arg231Stop |
| 300 | 73 | B | 0 | Mut | T | Negative | Arg282Trp |
| 109 | 43 | B | 0 | Mut | TG | Negative | Gly266Val |
| 14 | 70 | B | NA | Mut | TG | Negative | Arg196Stop |
| 15 | 58 | B | NA | Mut | TG | Negative | Arg213Stop |
| 38 | 58 | B | 0 | Mut | TG | Negative | Gly266Arg |
| 127 | 31 | C | 0 | Mut | G | Negative | Gly266Arg |
| 595 | 58 | C | 0 | Mut | G | Negative | Cys275Tyr |
| 63 | 74 | C | 0 | Mut | T | Negative | Pro152Leu |
| 190 | 58 | C | 0 | Mut | T | Negative | Tyr220Cys |
| 282 | 78 | C | 1 | Mut | T | Negative | Arg282Trp |
| 323 | 65 | C | 0 | Mut | T | Negative | Arg158Cys |
| 917 | 72 | C | 0 | Mut | T | Negative | Ile195Thr |
| 123 | 70 | C | 1 | Mut | T | Negative | Gly266Val |
| 238 | 72 | C | 0 | Mut | TG | Negative | Arg282Trp |
| 269 | 81 | C | 0 | Mut | TG | Negative | rg282Trp |
| 11880/01 | 62 | C | NA | Mut | TG | Negative | Gly266Arg |
| 71 | 55 | D | 1 | Mut | G | Negative | Arg282Trp |
| 304 | 65 | D | 0 | Mut | G | Negative | Arg282Trp |
| 4560/02 | 90 | D | NA | Mut | G | Negative | Tyr220His |
| 107 | 79 | D | 0 | Mut | T | Negative | Arg282Trp |
| 121 | 77 | D | 0 | Mut | T | Negative | Arg158His |
| 1013/03 | 65 | D | NA | Mut | T | Negative | Gly262Asp |
| 132 | 54 | D | 0 | Mut | TG | Negative | Arg196Stop |
| 28 | 57 | D | 1 | Mut | TG | Negative | Ser215Asn |
| 452/02 | 56 | NA | NA | Mut | TG | Negative | Arg282Trp |
| 939 | 64 | C | 0 | Mut | G | Negative | Arg282Trp |
| 20 | 76 | A | NA | Mut | T | Positive | Arg175His |
| 25 | 54 | A | 0 | Mut | TG | Positive | Arg175His |
| 27 | 62 | A | 0 | Mut | TG | Positive | Arg248Gln |
| 31 | 65 | A | 0 | Mut | TG | Positive | Gly245Asp |
| 138 | 80 | B | 0 | Mut | T | Positive | Gly245Asp |
| 145 | 73 | B | 0 | Mut | T | Positive | Arg175His |
| 12 | 78 | B | NA | Mut | T | Positive | Arg175His |
| 18 | 68 | B | NA | Mut | T | Positive | Arg175His |
| 19 | 86 | B | NA | Mut | T | Positive | Arg175His |
| 39 | 79 | B | 1 | Mut | T | Positive | Arg273Cys |
| 40 | 60 | B | 1 | Mut | T | Positive | Arg248Gln |
| 3 | 76 | B | 0 | Mut | TG | Positive | Arg248Trp |
| 52 | 70 | B | 0 | Mut | TG | Positive | Arg273His |
| 75 | 77 | B | 1 | Mut | TG | Positive | Pro250Leu |
| 151 | 79 | B | 1 | Mut | TG | Positive | Gly245Asp |
| 239 | 74 | B | 0 | Mut | TG | Positive | Arg273Cys |
| 29 | 65 | B | 0 | Mut | TG | Positive | Arg248Trp |
| 16 | 70 | C | 0 | Mut | T | Positive | Asp184Tyr |
| 26 | 64 | C | 0 | Mut | T | Positive | Ser241Thr |
| 72 | 73 | C | 1 | Mut | T | Positive | Gly245Asp |
| 139 | 49 | C | 1 | Mut | T | Positive | Arg175His |
| 226 | 55 | C | 0 | Mut | T | Positive | Arg273Cys |
| 13 | 59 | C | NA | Mut | T | Positive | Arg175His |
| 23 | 69 | C | 0 | Mut | T | Positive | Arg248Glu |
| 17 | 31 | C | 0 | Mut | TG | Positive | Arg248Trp |
| 104 | 61 | C | 1 | Mut | TG | Positive | Lys132Asn |
| 164 | 57 | C | 0 | Mut | TG | Positive | Arg273Cys |
| 165 | 76 | C | 1 | Mut | TG | Positive | Arg248Trp |
| 11 | 45 | C | NA | Mut | TG | Positive | Arg175His |
| 37 | 75 | C | 0 | Mut | TG | Positive | Arg273Cys |
| 664 | 72 | C | 1 | Mut | TG | Positive | Arg273His |
| 931 | 63 | C | 1 | Mut | TG | Positive | Gly245Ser |
| 981 | 56 | C | 1 | Mut | TG | Positive | Arg273His |
| 199 | 84 | D | 0 | Mut | G | Positive | Arg175His |
| 41 | 61 | D | NA | Mut | G | Positive | Arg175His |
| 101 | 48 | D | 1 | Mut | T | Positive | Arg175His |
| 986/03 | 68 | D | NA | Mut | T | Positive | Gly245Ser |
| 4561/02 | NA | D | NA | Mut | T | Positive | Arg248Trp |
| 989/03 | 46 | D | NA | Mut | TG | Positive | Arg273Leu |
| 920/03 | 80 | NA | NA | Mut | T | Positive | Cys117Arg |
| 929/03 | 73 | NA | NA | Mut | T | Positive | Gly245Ser |
| 454/02 | 70 | NA | NA | Mut | T | Positive | Arg175His |
| 938/03 | 67 | NA | NA | Mut | TG | Positive | Cys176Phe |
| 5574/01 | 80 | NA | NA | Mut | TG | Positive | Arg175His |
| 24 | 89 | B | NA | Mut | T | Positive | Arg273His |
| 23B | 67 | C | 1 | Mut | T | Positive | Gly245Asp |
| 26 | 64 | C | 1 | Mut | T | Positive | Arg248Gln |
| 33 | 79 | C | 0 | Mut | T | Positive | Arg175His |
| 35 | 61 | C | 1 | Mut | T | Positive | Arg248Gln |
| 22 | 76 | D | 1 | Mut | T | Positive | Arg175His |
*Early recurrence (<2 years from intervention) is indicated as positive (1) or negative (0).
†Dominant‐negative activity for the P53 mutation is indicated (experimental data available at the International Agency for Research on Cancer‐P53 Mutation Database http://www‐p53.iarc.fr/).
Mut, mutation; NA, not available.