Table 1 Association analyses of five single nucleotide polymorphisms in α‐T catenin (VR22) in two independent family samples.
| All families | z score (p) | ||||
|---|---|---|---|---|---|
| rs3750863 | rs4548513 (Ser596Asn) | rs7070570 | rs10996886 | rs2105702 | |
| NIMH (n = 437) | −0.2 (0.9) | −2.0 (0.04) | 0.8 (0.4) | 0.9 (0.4) | 0 (1) |
| CAG (n = 217) | ND | 0 (1) | ND | ND | ND |
| Late‐onset | |||||
| NIMH (n = 320) | 0.1 (0.9) | −2.3 (0.02) | 1.5 (0.1) | 1.6 (0.1) | −0.4 (0.7) |
| CAG (n = 155) | ND | 1.0 (0.3) | ND | ND | ND |
CAG, Consortium on Alzheimer's Genetics; ND, not done; NIMH, National Institute of Mental Health.
Minor allele frequencies in the NIMH (CAG) sample are rs3750863 (A) = 0.30 (ND), rs4548513 (Ser596Asn) (C (Ser)) = 0.36 (0.39), rs7070570 (G) = 0.29 (ND), rs10996886 (A) = 0.44 (ND), rs2105702 (C) = 0.31 (ND). z score for minor allele (positive values indicate overtransmission to affected individuals) using Family‐Based Association Test (V.1.5.5) after selecting an additive genetics model, the empirical variance function and an equal weight offset correction (see FBAT website for more details: http://www.biostat.harvard.edu/∼fbat/).