Table 2 Analysis of the common six marker haplotypes spanning GIMAP5 in five independent sample sets.
| T | U | OR | Low 95% CI | High 95% CI | p value | Haplotypes | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs759011 | rs1046355 | rs10361 | rs6598 | rs2286899 | rs2286898 | |||||||
| Finnish Caucasian trios (global p 0.046) | 42 | 26 | 1.52 | 0.99 | 2.63 | 0.05 | C | C | G | G | T | C |
| Finnish Caucasian sibships (global p n.s.) | 37 | 34 | 1.09 | 0.68 | 1.73 | 0.13 | C | C | G | G | T | C |
| UK Caucasian trios (global p not significant) | 119 | 95 | 1.25 | 0.96 | 1.64 | 0.1 | C | C | G | G | T | C |
| UK Asian (global p<0.07) | 11 | 3 | 3.67 | 1.02 | 13.2 | 0.03 | C | C | G | G | T | C |
| UK Caucasian sibships (global p not significant) | 85 | 92 | 0.92 | 0.69 | 1.24 | 0.27 | C | C | G | G | T | C |
All six marker haplotypes with frequency greater than 5% in the control chromosomes in the populations were analysed. rs3807383 is not in linkage disequilibrium with the other markers and falls outside the haplotype block as defined by Gabriel et al.28 Two‐sided p values are reported, except in the Asian sample, which is considered a replication and thus reported as one‐sided. A global p value was calculated for the distribution of haplotypes using 50 000 permutations in each population.
T, transmitted; U, undertransmitted.