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Figure 4 Partial nucleotide sequence of the cDNA generated by the mutant APOB minigene harbouring the c.4217–1G→T mutation in intron 25. The upper panel shows the junction between exons 25 and 26 in the cDNA generated by the wild‐type minigene. The lower panel shows that in mutant cDNA, exon 25 joins the partially deleted exon 26 (exon 25 joins the c.5397T corresponding to position 1181 from the beginning of exon 26). This junction causes a frameshift, leading to a premature stop codon.
