Figure 5 Histological examination of patient 2: liver with reticulin staining (A) and chondro‐osseous junction of the femur with haematoxylin and eosin staining (B). Note periportal hepatic fibrosis in the liver (black arrow). The chondro‐osseous junction shows foci of cystic lesions in the resting zone (white arrow) and poorly organised cartilage columns of the hypertrophic zone.