Figure 2 Schematic representation of the evolution of BRCA1 and BRCA2 mutation testing over the course of this study. Deleterious mutations in the French‐Canadian population reported in the literature were 2953delGTAinsC,²² R1443X,²¹ 3768insA,²⁴ W321X (Dr Elizabeth Springs, personal communication, 2000) and 2800delAA,⁴¹ 4184delTCAA (Breast Cancer Information Core, http://research.nhgri.nih.gov/bic/), 3875delGTCT and Q81X²⁵ in the BRCA1 gene; 2816insA (BCLC meeting, Lyon 1996, unpublished data,²⁴ 3034delAAAC,¹³ 8765delAG,²³ 6503delTT and E1953X,²⁴ 3773delTT (Breast Cancer Information Core, http://research.nhgri.nih.gov/bic) and 2558insA, 3398delAGAAA and 7235G→A²⁵ in the BRCA2 gene; and the sequence variant, T826K, in which a potential deleterious effect was suspected in the BRCA1 gene.²⁰