Figure 5 Receiver operating characteristic analysis of three BRCA1/BRCA2 mutation prediction algorithms showing sensitivity (ie, proportion of families with a BRCA1/BRCA2 mutation with a score or probability greater than or equal to a given threshold) plotted against 1−specificity (ie, proportion of families with scores below the threshold without an identified BRCA1/BRCA2 mutation). One point on the curve is obtained for each possible threshold. The area under the curve is used as a measure of the adequacy of the criteria used for genetic testing. MGL, Myriad Genetics Laboratories.