Table 3 Comparison of age at diagnosis in 191 families with at least one affected individual tested.
| Status | Families | Cases | ||
|---|---|---|---|---|
| n* | Mean (SD) | n | Mean† (SD) | |
| (A) Breast cancer | ||||
| BRCA1+ family | 26 | 45.1 (7.5) | 148 | 44.8 (11.7) |
| BRCA2+ family | 29 | 49.3 (5.9) | 191 | 48.6 (12.7) |
| No mutation detected | 135 | 53.1 (6.9) | 598 | 53.5 (12.4) |
| Overall: F2,187 = 26.3, p<0.0001; BRCA1/2v no mutation detected: F1,187 = 49.6, p<0.0001; BRCA1vBRCA2: F1,187 = 6.08, p = 0.015. | ||||
| (B) Ovarian cancer | ||||
| BRCA1+ family | 22 | 52.8 (8.7) | 42 | 52.1 (11.6) |
| BRCA2+ family | 11 | 56.1 (6.4) | 19 | 56.2 (10.2) |
| No mutation detected | 29 | 58.5 (12.1) | 35 | 58.4 (13.6) |
| Overall: F2,59 = 3.17, p = 0.04; BRCA1/2v no mutation detected: F1,59 = 3.13, p = 0.08; BRCA1vBRCA2: F1,59 = 1.74, p = 0.19. | ||||
BRCA1+, BRCA1 positive; BRCA2+, BRCA2 positive.
*Families with at least one case of breast or ovarian cancer, respectively.
†Analysis of variance of mean age at diagnosis per family, adjusted for number of cases.