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Table 1 Nicotine area under the concentration–time curve and maximal nicotine concentration for five smokeless products tested.

	Copenhagen	Commit	Stonewall	Ariva	Revel
AUC_0–90 (ng×min/ml)	1038 (806 to 1336)^a	467 (361 to 604)^b	292 (226 to 376)^b,c	192 (149 to 248)^c	189 (146 to 244)^c
C_max (ng/ml)	16.1 (12.1 to 21.5)^a	7.3 (5.5 to 9.8)^b	4.1 (3.1 to 5.4)^c	2.7 (2.0 to 3.6)^c	2.6 (2.0 to 3.5)^c

AUC_0–90, area under the concentration‐time curve for time 0 to 90 minutes; C_max, maximal nicotine concentration.

Data are adjusted geometric mean (95% CI). Products with different letters were significantly different (p<0.05).