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Table 2 Bivariate and multivariate regression analyses of trend and determinants of nicotine yield (mg/cig) from 1998 to 2005.

Nicotine yield in smoke (mg/cig) Bivariate analyses* Nicotine yield in smoke (mg/cig) multivariate analysis† Market category and design time trends‡
ββ§ (95% CI) p Value ββ§ (95% CI) p Value ββ¶ (95% CI) p Value
Time trend (years)
 All manufacturers 0.029 (0.010 to 0.044) 0.003 0.009 (0.006 to 0.011) <0.001
 Brown & Williamson 0.059 (0.049 to 0.069) <0.001
 Lorillard 0.030 (0.187 to 0.041) <0.001
 Philip Morris 0.011 (0.006 to 0.015) <0.001
 RJ Reynolds 0.020 (0.016 to 0.024) <0.001
Market category
 Length (⩾100 mm) 0.097 (0.005 to 0.190) 0.038 NS NS
 Mentholated vs non‐mentholated –0.043 (–0.137 to 0.051) 0.367 NS NS
 Candy‐flavoured vs non‐flavoured –0.099 (–0.194 to –0.004) 0.041 NS NS
 Full flavour vs non‐full flavour 0.348 (0.300 to 0.395) <0.001 0.187 (0.155 to 0.219) <0.001 0.006 (0.004 to 0.009) <0.001
 Filtered vs non‐filtered –0.092 (–0.221 to 0.036) 0.160 NS 0.002 (0.001 to 0.003) 0.001
Design feature
 Nicotine concentration (mg/g) 0.037 (0.032 to 0.042) <0.001 0.030 (0.025 to 0.034) <0.001 0.177 (0.147 to 0.207) <0.001
 Nicotine (mg) per cigarette 0.061 (0.055 to 0.067) <0.001 NS 0.135 (0.110 to 0.161) <0.001
 Puffs per cigarette 0.091 (0.079 to 0.103) <0.001 0.106 (0.098 to 0.113) <0.001 0.048 (0.035 to 0.060) <0.001
 Percentage filter ventilation –0.013 (–0.014 to –0.011) <0.001 –0.014 (–0.015 to –0.013) <0.001 NS
 Weight (g) 1.563 (1.325 to 1.801) <0.001 NS NS

cig, cigarette; NS, not significant.

*Each individual multilevel regression model consists of the Massachusetts (MA) regimen‐measured nicotine yield as the dependent variable, and one market category, design feature or time (in years) as the independent variable.

†Results are given for the multilevel mixed‐effects multiple regression model of MA regimen‐measured nicotine yield in smoke, including all significant parameters.

‡Each individual multilevel regression model consists of one market category or design feature as the dependent variable, and time as the independent variable.

§ β‐coefficients represent mg increase in nicotine yield in smoke per unit change of each parameter per year.

¶ β‐coefficients represent unit change of each parameter per year.