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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Anesthesiology. 2008 Jul;109(1):130–136. doi: 10.1097/ALN.0b013e31817b5ac3

Fig. 2. Effect of morphine on immunolabeled macrophages in the healing cutaneous wound.

Fig. 2

Cutaneous wounds were treated twice daily with IntraSite Gel (Smith+Nephew, Hull, United Kingdom) alone or gel infused with 5 mM morphine sulfate (MS). (A, B) Macrosialin-ir cells (arrows) in granulation tissue of healing wounds. Fluorescence photomicrographs of gel-only (A) and morphine-treated (B) wounds were obtained 1 day post-wounding. Note a significant decrease in the number of macrophages present in morphine-treated wounds as compared to controls. Scale bar = 100 μm. (C) Time course of macrophages present in the periwound area. Data are presented as number of macrosialin-ir cells per unit area (mm2) of histological sections analyzed. Macrophage infiltration is decreased and delayed in morphine-treated wounds (n=3 or 4). * p < 0.05 comparison between morphine and gel-only treated controls (two-way ANOVA, Tukey’s post-hoc test).