Figure 5.

Treatment with sTNFαR1 reduces injury-induced increases in synaptic AMPARs. A, Representative montages of adjacent tissue sections stained for Nissl and cFos, identifying the fos-positive SCI penumbra beyond the region of frank lesion. B, Representative high-resolution confocal stacks of GluR1/synaptophysin colocalization within the c-fos positive SCI penumbra after vehicle control or sTNFαR1 treatment. C, Quantitative results from algorithmic image analysis revealing reduced numbers of synaptic AMPARs in the spinal neuropil after treatment of SCI with sTNFαR1 (*p < 0.05 from vehicle and injury alone control conditions). Error bars indicate SEM.