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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Anesthesiology. 2008 Aug;109(2):243–250. doi: 10.1097/ALN.0b013e31817f5c47

Figure 3.

Figure 3

Isoflurane induced significantly greater decrease of the endoplasmic reticulum (ER) calcium than sevoflurane or desflurane only in DT40 wild type cells. DT40 wild type (WT) cells were permeabilized with saponin to allow the dye mag-fura 2/AM loaded into ER and then exposed to three inhalational anesthetics of isoflurane (Iso), sevoflurane (Sevo) and desflurane (Des) to induce calcium release from the ER (A). B and C. Isoflurane induced significantly more peak ER calcium decrease over its own baseline represented by the relative ratio (F340/F380) than Sevo or Des only in DT40 WT cells. Data represents mean±SD from at least three separate experiments. ***means P<0.001 compared to IP3 receptor total knock-out (TKO) DT40 cells. ### means P<0.001 compared to WT DT40 cells treated with either Sevo or Des.