Table 1.
Demographic characteristics, tobacco and alcohol consumption, tumor characteristics and treatment modality among HNSCC patients (N=135)
| Explanatory Variables | HPV16 positive N=44 (%) | HPV16 negative N=91 (%) | Fisher’s exact test p-value |
|---|---|---|---|
| DEMOGRAPHICS | |||
| Gender | 0.002 | ||
| Female | 3 (7) | 28 (31) | |
| Male | 41 (91) | 63 (69) | |
| Age | 0.02 | ||
| <50 | 14 (32) | 24 (26) | |
| 50–64 | 26 (59) | 40 (44) | |
| ≥ 65 | 4 (9) | 27 (30) | |
| Race and ethnicity | 0.01 | ||
| White, non-Hispanic | 43 (98) | 75 (82) | |
| Black, non-Hispanic | 0 (0) | 13 (14) | |
| Other | 1 (2) | 3 (3) | |
| SMOKINGa | |||
| Pack-years smoked (cigarettes, cigar or pipe) | 0.002 | ||
| Non-smoker | 24 (55) | 27 (30) | |
| 1 to 19 | 9 (20) | 9 (10) | |
| ≥ 20 | 8 (18) | 36 (40) | |
| Unknown | 3 (7) | 19 (21) | |
| DRINKINGa | 0.12 | ||
| Number of years drank ≥ 15 drinks per Week | |||
| Non-drinker | 29 (66) | 44 (48) | |
| 1 to 14 | 4 (9) | 7 (8) | |
| ≥ 15 | 9 (18) | 21 (23) | |
| Unknown | 3 (7) | 19 (21) | |
| TUMOR CHARACTERISTICS | |||
| AJCC TNM stage | <0.0001 | ||
| Stage 0 | 1 (2) | 3 (3) | |
| Stage I | 1 (2) | 34 (37) | |
| Stage II | 2 (5) | 19 (21) | |
| Stage III | 4 (9) | 14 (15) | |
| Stage IV | 36 (82) | 21 (23) | |
| Tumor anatomic site | <0.0001 | ||
| Lip and oral cavity | 0 (0) | 43 (47) | |
| Oropharynx | 41 (93) | 11 (12) | |
| Nasopharynx | 0 (0) | 1 (1) | |
| Hypopharynx | 0 (0) | 4 (4) | |
| Larynx | 0 (0) | 26 (29) | |
| Paranasal sinuses | 0 (0) | 5 (5) | |
| Unknown primary | 3 (6) | 1 (1) | |
| Primary treatment modality | <0.0001 | ||
| Surgery ± adjuvant radiation | 31 (70) | 87 (96) | |
| Radiation alone | 2 (5) | 3 (3) | |
| Chemoradiation | 11 (25) | 1 (1) | |
| Tumor recurrence | 0.11 | ||
| No | 35 (80) | 59 (65) | |
| Yes | 9 (20) | 32 (35) | |
| Second primary diagnosisb | |||
| No | 44 (100) | 80 (88) | 0.016 |
| Yes | 0 (0) | 11 (12) | |
a
22 patients did not complete the audio computer-assisted self-interview and have missing smoking and alcohol consumption data
b
Second primary cancers included head and neck, lung, and esophageal cancers.