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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Clin Cancer Res. 2008 Nov 1;14(21):7143–7150. doi: 10.1158/1078-0432.CCR-08-0498

Table 1.

Demographic characteristics, tobacco and alcohol consumption, tumor characteristics and treatment modality among HNSCC patients (N=135)

Explanatory Variables HPV16 positive N=44 (%) HPV16 negative N=91 (%) Fisher’s exact test p-value

DEMOGRAPHICS
Gender 0.002
 Female 3 (7) 28 (31)
 Male 41 (91) 63 (69)
Age 0.02
 <50 14 (32) 24 (26)
 50–64 26 (59) 40 (44)
 ≥ 65 4 (9) 27 (30)
Race and ethnicity 0.01
 White, non-Hispanic 43 (98) 75 (82)
 Black, non-Hispanic 0 (0) 13 (14)
 Other 1 (2) 3 (3)
SMOKINGa
Pack-years smoked (cigarettes, cigar or pipe) 0.002
 Non-smoker 24 (55) 27 (30)
 1 to 19 9 (20) 9 (10)
 ≥ 20 8 (18) 36 (40)
Unknown 3 (7) 19 (21)
DRINKINGa 0.12
Number of years drank ≥ 15 drinks per Week
 Non-drinker 29 (66) 44 (48)
 1 to 14 4 (9) 7 (8)
 ≥ 15 9 (18) 21 (23)
 Unknown 3 (7) 19 (21)
TUMOR CHARACTERISTICS
AJCC TNM stage <0.0001
 Stage 0 1 (2) 3 (3)
 Stage I 1 (2) 34 (37)
 Stage II 2 (5) 19 (21)
 Stage III 4 (9) 14 (15)
 Stage IV 36 (82) 21 (23)
Tumor anatomic site <0.0001
 Lip and oral cavity 0 (0) 43 (47)
 Oropharynx 41 (93) 11 (12)
 Nasopharynx 0 (0) 1 (1)
 Hypopharynx 0 (0) 4 (4)
 Larynx 0 (0) 26 (29)
 Paranasal sinuses 0 (0) 5 (5)
 Unknown primary 3 (6) 1 (1)
Primary treatment modality <0.0001
 Surgery ± adjuvant radiation 31 (70) 87 (96)
 Radiation alone 2 (5) 3 (3)
 Chemoradiation 11 (25) 1 (1)
Tumor recurrence 0.11
 No 35 (80) 59 (65)
 Yes 9 (20) 32 (35)
Second primary diagnosisb
 No 44 (100) 80 (88) 0.016
 Yes 0 (0) 11 (12)
a

22 patients did not complete the audio computer-assisted self-interview and have missing smoking and alcohol consumption data

b

Second primary cancers included head and neck, lung, and esophageal cancers.