Table 2.
Detection of HPV16 and any of 36 non-HPV16 mucosal HPV types in pre and post therapy oral rinse samples by tumor HPV status (N=135)
| Tumor HPV status | ||||
|---|---|---|---|---|
| HPV16-positive N=442 | HPV16-negative N=911 | Odds Ratio (95% CI) | ||
| Oral infection | N (%) | N (%) | Unadjusted | Adjusted3 |
| HPV16 | ||||
| AT DIAGNOSIS | ||||
| Infection absent | 30 (70) | 86 (97) | 1.0 | 1.0 |
| Infection present | 13 (30) | 3 (3) | 12 (3.3, 47) | 9.6 (2.4, 39) |
| FOLLOW-UP | ||||
| Infection absent | 39 (89) | 90 (99) | 1.0 | 1.0 |
| Infection present | 5 (11) | 1 (1) | 11 (1.1, 114) | 14 (1.1, 188) |
| High risk HPV types (non-HPV16)4 | ||||
| AT DIAGNOSIS | ||||
| Infection absent | 36 (84) | 87 (98) | 1.0 | 1.0 |
| Infection present | 7 (16) | 2 (2) | 5.6 (1.4, 23) | 5.4 (1.3, 22)6 |
| FOLLOW-UP | ||||
| Infection absent | 32 (73) | 79 (87) | 1.0 | 1.0 |
| Infection present | 12 (27) | 12 (13) | 2.9 (1.1, 7.6) | 2.9 (1.4, 5.7) |
| Low risk HPV types5 | ||||
| AT DIAGNOSIS | ||||
| Infection absent | 37 (86) | 86 (97) | 1.0 | 1.0 |
| Infection present | 6 (14) | 3 (3) | 4.7 (1.7, 20) | 4.5 (1.1, 19)6 |
| FOLLOW-UP | ||||
| Infection absent | 40 (91) | 82 (90) | 1.0 | 1.0 |
| Infection present | 4 (9) | 9 (10) | 0.6 (0.2, 2.1) | 0.6 (0.2, 1.5) |
1
Two HPV16-negative cases had missing baseline HPV line-blot data
2
One HPV16-positive case had missing baseline HPV line-blot data
3
Adjusted for age, gender, race
4
High risk HPV types 18, 33, 35, 51, 52, 56, 58, 59, 67, 68, 73 detected by PCR/line blot hybridization
5
Low risk HPV types 6, 11, 42, 55, 61, 62, 69, 72 detected by PCR/line blot hybridization 6 Adjusted for age only due to lack of model fit with inclusion of race and gender in model