Table 3.

emographic and lifestyle determinants of nicotine equivalents and CYP2A6 activity (n=585)^*

Dependent Variable	R2 (%)	Independent Variables	Regression coefficient	P-value
Nicotine Equivalents†	32.9	Age (years)	−0.041	0.26
		Native Hawaiian vs. white	−0.067	0.12
		Japanese Am. vs. white	−0.193	<0.0001
		Male vs. female	0.143	0.0001
		Cigarettes per day	0.157	<0.0001
		BMI (kg/m2)	0.017	0.65
		Urine Volume (mL)	−0.510	<0.0001
		Tot Fruits (g/kcal/day)	−0.023	0.52
		Tot Vegetables (g/kcal/day)	−0.025	0.50
		Soy (g/kcal/day)	0.028	0.45
		Caffeine (mg/kcal/day)	0.088	0.01
		Alcohol (g/kcal/day)	0.022	0.58
Nicotine Metabolite Ratio‡	14.4	Age (years)	−0.030	0.47
		Native Hawaiian vs. white	−0.121	0.01
		Japanese Am. vs. white	−0.321	<0.0001
		Male vs. female	−0.002	0.96
		Cigarettes per day	0.116	0.01
		BMI (kg/m2)	−0.142	0.001
		Urine Volume (mL)	−0.153	0.0003
		Tot Fruits (g/kcal/day)	−0.035	0.38
		Tot Vegetables (g/kcal/day)	0.030	0.47
		Soy (g/kcal/day)	0.032	0.45
		Caffeine (mg/kcal/day)	0.0003	0.99
		Alcohol (g/kcal/day)	0.102	0.02
Caffeine Metabolite Ratio§	12.2	Age (years)	0.113	0.01
		Native Hawaiian vs. white	−0.096	0.05
		Japanese Am. Vs. white	−0.284	<0.0001
		Male vs. female	−0.128	0.002
		Cigarettes per day	0.055	0.19
		BMI (kg/m2)	0.104	0.02
		Urine Volume (mL)	−0.096	0.03
		Tot Fruits (g/kcal/day)	−0.123	0.003
		Tot Vegetables (g/kcal/day)	−0.048	0.25
		Soy (g/kcal/day)	0.064	0.14
		Caffeine (mg/kcal/day)	−0.005	0.91
		Alcohol (g/kcal/day)	0.008	0.86

^*Data are for three separate multiple linear regression models.

^†Nicotine equivalents estimated by the sum of urinary levels of total nicotine, total cotinine, and total 3′-hydroxycotinine (3-HC); expressed as nmol/mL.

^‡Nicotine metabolite ratio is the ratio of total 3-HC to total cotinine measured in a 12-hour urine sample.

^§Caffeine metabolite ratio is the ratio of 1,7-dimethyl uric acid (17U) to 1,7-dimethylxanthine (17X) measured 5-hours after caffeine administration.