TABLE 1.
Model parameter values
| Value | Value | |||
|---|---|---|---|---|
| Symbol | Definition | ATP model | GJ model | |
| VA (mM s−1) | Glu release rate (astrocyte) | 600 | 500 | Fitted |
| λA (s−1) | Decay rate | 10 | 10 | Fitted |
| VB (mM s−1) | Glu release rate (neuron) | 600 | 500 | Fitted |
| λB (s−1) | Decay rate | 10 | 10 | Fitted |
| KGlu | G-protein activation constant | 8.82 | 8.82 | cf. (29). |
| KRGlu (μM) | G-protein binding constant | 5 | 5 | Fitted |
| KATP | G-protein activation constant | 8.82 | 8.82 | (29) |
| KRATP (μM) | G-protein binding constant | 2.5 | 2.5 | (29) |
| rh (μmol μm−2 s−1) | IP3 production rate (ATP) | 2 × 10−14 | 7 × 10−14 | (29) |
| γ (s−1) | G-J strength | 3 | Fitted | |
| KCa (μM) | PLCδ activation constant | 0.3 | (37) | |
| rhd (μmol μm−2 s−1) | IP3 production rate (PLCδ) | 5 × 10−16 | Fitted | |
| DNa (μm2 s−1) | Diffusion coefficient for Na+ | 1.33 × 103 | 1.33 × 103 | (48) |
| DK (μm2 s−1) | Diffusion coefficient for K+ | 1.96 × 103 | 1.96 × 103 | (48) |
| DCl (μm2 s−1) | Diffusion coefficient for Cl− | 2.03 × 103 | 2.03 × 103 | (48) |
| DCa (μm2 s−1) | Diffusion coefficient for Ca2+ | 0.79 × 103 | 0.79 × 103 | (48) |
Some values are available in the literature, as indicated; others have been chosen to fit experimental data.