FIGURE 9.

Comparison of the behavior of the Michaelis-Menten model used as the true system and the models screened using a network with inconsistent regulatory connections. In this case, we remove the feedback inhibition of PEP on the Pfk flux in the ensemble network. Even with the inconsistent regulatory pattern between models, we see a similar behavior when each enzyme is overexpressed twofold. However, when PGI is overexpressed, we see a difference in model behavior directly upstream of the missing regulatory feature of PEP as an inhibitor to Pfk.